Table of Contents
VETERINARY MEDICINE
Wildlife Pharmaceuticals specialises in the local and international distribution of scheduled veterinary medicines
SCHEDULING STATUS
S4
COMPOSITION
Each ml contains: Diprenorphine HCl 12 mg
Preservative: Chlorocresol 0,1 % m/v
CATEGORY AND CLASS OF MEDICINE
C 1.3.2 Opioid antagonist
PHARMACOLOGICAL ACTION
Diprenorphine is a relatively potent antagonist of the oripavine series that binds with equal affinity to µ-, δ- and κ-opioid receptors. Although its action is much closer to that of an antagonist and it is routinely used as a reversal agent for potent opioid agonists, it does retain some agonistic activity. Diprenorphine has no analgesic activity in rodents and primates, suggesting a lack of agonistic activity at the µ-opioid receptors although some agonistic activity has been found at κ-opioid receptors in these species.
PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES
Diprenorphine has a quick onset of action following administration and is rapidly metabolized. When given intramuscularly, it takes 10-20 minutes to reverse the effects of etorphine while intravenous administration shows a faster onset of action of 2-5 minutes. In mice treated with etorphine, the antagonistic effect of diprenorphine peaked 30 minutes after subcutaneous administration with a duration of action exceeding 90 minutes.
INDICATIONS
ACTIVON is indicated for the reversal of CAPTIVON (etorphine HCl) immobilization in wildlife animals.
CONTRAINDICATIONS
None recorded.
WARNINGS
Opioids may be less effective if wildlife animals are to be re-immobilized within 24 hours following treatment with ACTIVON, and an alternative immobilization protocol should be considered in such cases.
The safety of ACTIVON in pregnant and lactating wildlife animals has not been established.
ACTIVON residue studies have not been conducted in wildlife animals and consequently, human and predator consumption of carcasses from animals treated with ACTIVON is not advisable.
DOSAGE AND DIRECTIONS FOR USE
Administration by intravenous or intramuscular injection is recommended. Refer to the table below for ACTIVON dosing.
| Wildlife species | CAPTIVON 98 dose | ACTIVON dose |
| Elephant, rhino and giraffe | 1 mg | 3-5 mg |
| Other | 1 mg | 2-3 mg |
SIDE EFFECTS AND SPECIAL PRECAUTIONS FOR USE
ACTIVON may produce sedation and other opioid effects due to its partial agonistic activity. A degree of sedation may persist following reversal of CAPTIVON with ACTIVON and this should be considered when using ACTIVON in prey species that are to be released in predator areas. In white rhino, ACTIVON does not antagonize the effects of CAPTIVON completely and the animal may remain partially narcotized for up to eight hours following the administration of ACTIVON.
Accidental exposure to ACTIVON could have serious effects on humans due to the high concentration of the medicine. The following precautions should be taken by veterinarians when using ACTIVON:
- Do not work with ACTIVON unaccompanied.
- Wear gloves when handling ACTIVON. Ensure water or an appropriate irrigation solution is available to treat accidental exposure of the skin or eyes.
- Once the required dose of ACTIVON has been withdrawn from the vial, the needle should be immediately discarded into a closed container or sharps bin.
- ACTIVON should not be used in blowpipes or similar devices where the medicine solution is pressurized.
- ACTIVON should not be used as an antagonist in the event of accidental human exposure to CAPTIVON.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
Overdosing with ACTIVON may cause continued immobilization due to its partial agonistic activity.
IDENTIFICATION
A clear, colorless solution free from visible particulate matter.
PRESENTATION
ACTIVON is supplied in a 10 ml amber vial with a grey stopper and a silver aluminium.
STORAGE INSTRUCTIONS
Store at or below 25 °C.
Protect from light.
Once the rubber stopper has been pierced, the contents of the vial must be used within two weeks.
KEEP OUT OF REACH OF CHILDREN AND UNINFORMED PERSONS.
REGISTRATION NUMBER
93/1.3.2/8
NAME AND BUSINESS ADDRESS OF HOLDER OF CERTIFICATE OF REGISTRATION
Wildlife Pharmaceuticals (Pty) Ltd. 38 Wilkens Street, Rocky Drift, White River,1240, South Africa.
OUR PRODUCTS
Make a difference in wildlife healthcare today!
Explore our range of specialised wildlife veterinary solutions
Empowering wildlife care with cutting edge solutions. At Wildlife Pharmaceuticals, we offer specialised products for the chemical immobilisation of wild and exotic animals.
Our comprehensive range includes wildlife anaesthetics, sedatives, tranquilisers and antidotes and Pneu-Dart products, designed for precise delivery of medications.
With our top-tier solutions, veterinarians, researchers and wildlife professionals can safely and effectively manage and care for diverse animal species, contributing to conservation efforts and welfare of wildlife populations worldwide.
Wildlife Medicine
Chemical immobilising medicines & antidotes
- [S4] ZOOSEDIN 20 (atipamezole HCl 20 mg/ml)
- [S5] SEDOLAM 50 (midazolam HCl 50 mg/ml)
- [S6] THIANIL (thiafentanil oxalate 10 mg/ml)
- [S4] TREXONIL (naltrexone HCl 50 mg/ml)
- [S6] CAPTIVON 98 (etorphine HCl 9.8 mg/ml)
- [S4] ACTIVON (diprenorphine HCl 12 mg/ml)
Pneu-Dart Products
We also offer essential delivery method equipment for your convenience
Investigational Medicines
Wildlife Pharmaceuticals offers a range of investigational medicines to veterinarians
Read More: VETERINARY MEDICINES
OUR SERVICES
Wildlife Pharmaceuticals specialises in the local and international distribution of scheduled veterinary medicines
API Manufacturing
Wildlife Pharmaceuticals excels in API manufacturing for veterinary medicine manufacturers with a focus on quality and adherence to industry standards.
Read More: API MANUFACTURING
Sterile Filling
Wildlife Pharmaceuticals is leading the pharmaceutical manufacturing industry with innovative cGMP approaches and advanced robotic systems
Read More: STERILE FILLING