THIANIL
VETERINARY MEDICINE
Wildlife Pharmaceuticals specialises in the local and international distribution of scheduled veterinary medicines
SCHEDULING STATUS
S6
COMPOSITION
Each ml contains: Thiafentanil oxalate 10 mg
Preservative: Methylparaben 0,1 % m/v
CATEGORY AND CLASS OF MEDICINE
C 1.3.1 Opioid agonist
PHARMACOLOGICAL ACTION
Thiafentanil oxalate is a pure opioid agonist that produces analgesia, immobilisation and profound anaesthesia in wildlife animals. It is a synthetic analogue of fentanyl and has selective affinity for the μ-opioid receptors found throughout the central nervous system. When thiafentanil is used alone in wildlife animals, the anaesthesia produced is characterised by extensive muscle rigidity, typical of opioid anaesthesia in most large ungulates. Thiafentanil is fully reversed by naltrexone hydrochloride which competitively binds to and displaces thiafentanil from the opioid receptors.
PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES
Thiafentanil is lipid soluble and rapidly absorbed and metabolised following intramuscular injection. It has a rapid onset of action and a relatively short duration of action.
INDICATIONS
THIANIL is indicated for reversible narcosis with analgesia in wildlife animals.
CONTRAINDICATIONS
THIANIL is contraindicated in felid species and non-domestic equids, specifically Burchell’s zebra (Equus quagga burchellii).
WARNINGS
THIANIL residue studies have not been conducted in wildlife animals and consequently, carcasses from animals treated with THIANIL should not be used for human or predator consumption. A withdrawal period of at least 3 months is required.
DOSAGE AND DIRECTIONS FOR USE
The effects of THIANIL can be reversed by administering TREXONIL (naltrexone hydrochloride) at a ratio of 10 mg of TREXONIL for every 1 mg of THIANIL used. Personnel should retreat sufficiently prior to reversal of THIANIL as animals may rise in as little as 30 seconds after intravenous administration of TREXONIL.
SIDE EFFECTS AND SPECIAL PRECAUTIONS FOR USE
Precautionary steps must be taken to prevent the effects of extreme environmental temperatures on anaesthetised animals. The use of THIANIL in elderly animals and animals with compromised health carries an additional degree of risk.
Accidental exposure to THIANIL could have serious effects on humans due to the high concentration of the medicine. The following precautions should be taken by veterinarians when using THIANIL:
- Do not work with THIANIL when unaccompanied.
- Wear gloves when handling THIANIL. Ensure water or an appropriate irrigation solution is available to treat accidental exposure of the skin or eyes.
- Ensure that the antidote (naloxone) and a needle and syringe for administration of the antidote are readily available. An assistant capable of administering the antidote to humans should be present at all times and should be fully briefed on the procedure to follow in the event of accidental exposure to THIANIL.
- Once the required dose of THIANIL has been withdrawn from the vial, the needle should be immediately discarded into a closed container or sharps bin.
- THIANIL should not be used in blowpipes or similar devices where the medicine solution is pressurised.
- Symptoms of toxicity in humans include dizziness, nausea, pinpoint pupils, cyanosis, respiratory depression, hypotension, loss of consciousness and cardiac arrest.
- In the event of accidental topical exposure of the skin or eyes, wash the affected area immediately with copious amounts of water to prevent absorption. Monitor for symptoms of toxicity.
- Should accidental injection occur, seek medical attention immediately. Inject the antidote intramuscularly or intravenously and repeat at 2-3 minute intervals until symptoms are reversed. Monitor airway and ventilation and initiate CPR as necessary until medical help arrives.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
Symptoms of toxicity in wildlife animals include respiratory depression and/or severe cardiovascular changes. Should respiratory function not recover sufficiently, TREXONIL or small increments of BUTADYNE 50 (butorphanol tartrate) can be administered. Oxygen supplementation is recommended in the case of severe respiratory depression.
IDENTIFICATION
A clear, colourless solution free from visible particulate matter.
PRESENTATION
THIANIL is supplied in a clear 10 ml vial with a red stopper and silver aluminium cap.
STORAGE INSTRUCTIONS
Store at or below 25 °C.
Protect from light.
KEEP OUT OF REACH OF CHILDREN AND UNINFORMED PERSONS.
REGISTRATION NUMBER
06/1.3/06
NAME AND BUSINESS ADDRESS OF HOLDER OF CERTIFICATE OF REGISTRATION
Wildlife Pharmaceuticals (Pty) Ltd. 38 Wilkens Street, Rocky Drift, White River,1240, South Africa.
OUR PRODUCTS
Make a difference in wildlife healthcare today!
Explore our range of specialised wildlife veterinary solutions
Empowering wildlife care with cutting edge solutions. At Wildlife Pharmaceuticals, we offer specialised products for the chemical immobilisation of wild and exotic animals.
Our comprehensive range includes wildlife anaesthetics, sedatives, tranquilisers and antidotes and Pneu-Dart products, designed for precise delivery of medications.
With our top-tier solutions, veterinarians, researchers and wildlife professionals can safely and effectively manage and care for diverse animal species, contributing to conservation efforts and welfare of wildlife populations worldwide.
Wildlife Medicine
Chemical immobilising medicines & antidotes
- [S4] ZOOSEDIN 20 (atipamezole HCl 20 mg/ml)
- [S5] SEDOLAM 50 (midazolam HCl 50 mg/ml)
- [S6] THIANIL (thiafentanil oxalate 10 mg/ml)
- [S4] TREXONIL (naltrexone HCl 50 mg/ml)
- [S6] CAPTIVON 98 (etorphine HCl 9.8 mg/ml)
- [S4] ACTIVON (diprenorphine HCl 12 mg/ml)
Pneu-Dart Products
We also offer essential delivery method equipment for your convenience
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